tag:blogger.com,1999:blog-35810531076579609862024-03-06T06:24:31.344+00:00A Hungarian Vizsla Health ProblemA new disease called Vizsla Polymyositis has been recognised. The dogs have swallowing problems, eating difficulties and usually also muscle wasting around the head.Unknownnoreply@blogger.comBlogger1125tag:blogger.com,1999:blog-3581053107657960986.post-22451432457780366002007-06-27T12:59:00.086+00:002019-07-24T19:35:01.219+00:00Vizsla Myositis/Polymyositis<h2>
<span style="font-family: inherit;"><span style="color: #666666;"><span style="font-size: 85%;"><span style="font-size: 100%;"><span style="font-size: 130%;"><span style="font-size: small;"> </span></span></span></span></span></span></h2>
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<span style="color: blue;"><span style="font-family: inherit;"><span style="color: #666666;"><span style="font-size: 85%;"><span style="font-size: 100%;"><span style="font-size: 130%;"><span style="font-size: small;">THIS BLOG HAS BEEN REPLACED BY A <a href="https://www.vizslahealth.net/polymyositis/" target="_blank">DEDICATED WEBSITE</a></span></span></span></span></span></span></span></h2>
<span style="font-family: inherit;"><span style="color: #666666;"><span style="font-size: 85%;"><span style="font-size: 100%;"><span style="font-size: 130%;"><span style="font-size: small;"><br />There is a newly recognised disease in the Hungarian Vizsla. It is a breed specific presentation of Polymyositis. The principal clinical signs are </span></span></span></span></span></span><br />
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<li><span style="font-family: inherit;"><span style="color: #666666;"><span style="font-size: 85%;"><span style="font-size: 100%;"><span style="font-size: 130%;"><span style="font-size: small;">swallowing problems, </span></span></span></span></span></span></li>
<li><span style="font-family: inherit;"><span style="color: #666666;"><span style="font-size: 85%;"><span style="font-size: 100%;"><span style="font-size: 130%;"><span style="font-size: small;">excessive foamy drooling </span></span></span></span></span></span></li>
<li><span style="font-family: inherit;"><span style="color: #666666;"><span style="font-size: 85%;"><span style="font-size: 100%;"><span style="font-size: 130%;"><span style="font-size: small;">muscle wasting (especially around the head)</span></span></span></span></span></span></li>
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<span style="font-family: inherit;"><span style="color: #666666;"><span style="font-size: 85%;"><span style="font-size: 100%;"><span style="font-size: 130%;"><span style="font-size: small;"><br /><a href="http://vetneuromuscular.ucsd.edu/cases/2007/Sept07.html">Visit</a> a description on the website of the Comparitive <span style="font-size: small;">N</span>euromuscular Laboratory in San Diego.<br /><br /><span style="color: #073763;"><a href="http://www.veterinary-neurologist.co.uk/Vizsla_Polymyosits/" target="_blank">Visit</a></span> the website of RCVS and European Specialist in Veterinary Neurology - Clare Rusbridge - (BVMS, PhD, DipECVN, MRCVS) for disease information.</span></span></span></span></span></span><br />
<span style="font-family: inherit;"><span style="color: #666666;"><span style="font-size: 85%;"><span style="font-size: 100%;"><span style="font-size: 130%;"><span style="font-size: small;"><br /></span></span></span></span></span></span><span style="color: #073763;"><a href="http://www.veterinary-neurologist.co.uk/docs/vizsla_dna%20_collection_%20pack%5B1%5D.pdf" target="_blank">Visit</a></span><span style="font-family: inherit;"><span style="color: #666666;"><span style="font-size: 85%;"><span style="font-size: 100%;"><span style="font-size: 130%;"><span style="font-size: small;"> a website that describes a DNA sample collection scheme.<br /><br />Scroll right down for a great deal more information on polymyositis in affected UK vizslas and there is also some guidance to help vets reach a correct diagnosis by distinguishing the condition from other myopathies.<br /><br />Please also look at the links in the adjoining sidebar for some video clips and other useful information. The following images illustrate typical muscle wasting in the temporal and masseter areas (click on each for a high resolution picture)</span></span></span></span></span></span><br />
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<tr><td style="text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEg043-l1pumjKIxhVfV9ESLbGzUTk5_ePQU85qPT44cjhLHVNKNUSwZEVxxNSZIo5UIdAvULWqYBnBVsWXYzUOPoFF2LwYR6IYHhiBL5FqN3tKtEf7e8jeGRLB-5S_jV466B6sFTaYAhZYq/s1600-h/mika+drool+cropped.jpg" style="clear: left; margin-bottom: 1em; margin-left: auto; margin-right: auto;"><img alt="" border="0" height="265" id="BLOGGER_PHOTO_ID_5238552336882201778" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEg043-l1pumjKIxhVfV9ESLbGzUTk5_ePQU85qPT44cjhLHVNKNUSwZEVxxNSZIo5UIdAvULWqYBnBVsWXYzUOPoFF2LwYR6IYHhiBL5FqN3tKtEf7e8jeGRLB-5S_jV466B6sFTaYAhZYq/s320/mika+drool+cropped.jpg" width="320" /></a></td></tr>
<tr><td class="tr-caption" style="text-align: center;"><span style="color: #0b5394;">mika</span></td></tr>
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<tr><td style="text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgEMPWzCc4wfxXbV7EWTiqS-5EpeAxIsRIc37l4QVmpzOr9EsM25EqyBrMtFpnJyr2GgmWHCnEoB9Tm2-4dpzuTijPaUok797EaJlit4ww1E-ziWru7NNylppC1GCLaXTMDaBtdi_mOCXwU/s1600-h/bodri+cropped.jpg" style="clear: right; margin-bottom: 1em; margin-left: auto; margin-right: auto;"><img alt="" border="0" height="186" id="BLOGGER_PHOTO_ID_5300102030399873698" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgEMPWzCc4wfxXbV7EWTiqS-5EpeAxIsRIc37l4QVmpzOr9EsM25EqyBrMtFpnJyr2GgmWHCnEoB9Tm2-4dpzuTijPaUok797EaJlit4ww1E-ziWru7NNylppC1GCLaXTMDaBtdi_mOCXwU/s200/bodri+cropped.jpg" width="200" /></a></td></tr>
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<tr><td style="text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgwAcv-2ocW9wkrlds-nFDSHsmrxwfohB1e1FB2ZwfpezA4RUobnQI2ZieMqBaYqpB4Nlp-f5eXO0__NdXpf1GcuAwcHa-xyBoYejfohaSoxPEV-GetfAgP6RHZHZHZ8__SdCgpBqvLWu3U/s1600-h/amber+for+website.jpg" style="clear: right; margin-bottom: 1em; margin-left: auto; margin-right: auto;"><img alt="" border="0" height="180" id="BLOGGER_PHOTO_ID_5238556636133026178" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgwAcv-2ocW9wkrlds-nFDSHsmrxwfohB1e1FB2ZwfpezA4RUobnQI2ZieMqBaYqpB4Nlp-f5eXO0__NdXpf1GcuAwcHa-xyBoYejfohaSoxPEV-GetfAgP6RHZHZHZ8__SdCgpBqvLWu3U/s200/amber+for+website.jpg" width="200" /></a></td></tr>
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<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgDfS6L59NwxlxCvEbIb9J2289BMBbgZ9VS6ZZA_zXVFFCKgkJoPUpCwBdRWS-SHfvDSIqxxbpWEQXAPomfkdYt5l6S8DvKOqJztfHLChit2RrUpge-dElKyz0Hl54dmaUv-e1wESp3jJRT/s1600-h/Radio.JPG" style="margin-left: auto; margin-right: auto;"><img alt="" border="0" height="133" id="BLOGGER_PHOTO_ID_5296475346724481762" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgDfS6L59NwxlxCvEbIb9J2289BMBbgZ9VS6ZZA_zXVFFCKgkJoPUpCwBdRWS-SHfvDSIqxxbpWEQXAPomfkdYt5l6S8DvKOqJztfHLChit2RrUpge-dElKyz0Hl54dmaUv-e1wESp3jJRT/s200/Radio.JPG" style="height: 213px; width: 320px;" width="200" /></a></td></tr>
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<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgwAcv-2ocW9wkrlds-nFDSHsmrxwfohB1e1FB2ZwfpezA4RUobnQI2ZieMqBaYqpB4Nlp-f5eXO0__NdXpf1GcuAwcHa-xyBoYejfohaSoxPEV-GetfAgP6RHZHZHZ8__SdCgpBqvLWu3U/s1600-h/amber+for+website.jpg" style="clear: right; float: right; margin-bottom: 1em; margin-left: 1em;"></a><span style="font-size: 85%;"><br /></span>
<span style="color: #666666;"><span style="font-size: x-small;"><span style="font-size: small;">Recently here in the UK there has been a very worrying number of young Hungarian Vizslas diagnosed with myositis (muscle inflammation) or polymyositis. Typical onset is usually in adolescence or maybe up to about two years of age (worryingly though some recent cases have been considerably later) and frequently there is an initial acute episode of retching, gagging, choking, dysphagia and hypersalivation. Sometimes the onset is more insidious with inefficient and messy eating and drinking being noted. Often there is an initial diagnosis of megaoesophagus. Fatigue, significantly elevated CK levels, an absence of a gag reflex, voice change, aspiration pneumonia and lameness/stiffness of gait are other common findings. Muscle wasting in the temporal and masseter areas usually follows.</span><span style="font-size: small;"><br /></span><br /><span style="font-size: small;">We think the illness is immune mediated and on the basis of several very close family relationships (siblings for example) we believe it to be genetic. </span><span style="font-size: small;"><br /></span><span style="font-size: small;"><br /></span><span style="font-size: small;">Where cases have been fully investigated, infectious causes of muscle inflammation (such as neosporosis or toxoplasmosis) are invariably ruled out. So too are myaesthenia gravis and masticatory muscle myositis.</span><span style="font-size: small;"> </span></span></span><br />
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<span style="color: #666666;"><span style="font-size: x-small;"><span style="font-size: small;">With prompt diagnosis and treatment polymyositis can usually be well controlled with combined <i>immune suppressive</i> protocols - typically Prednisone + Imuran (azathioprine) + gastroprotectants - these medications to be only very gradually tapered. Recently some specialists have also introduced Cyclosporine/Atopica (another immune suppressant) Careful monitoring of these regimes is vital</span>. </span><span style="font-size: x-small;"><a href="http://www.vizslahealth.net/muscle%20disease%20in%20the%20vizsla%20PDF.pdf" target="_blank"><span style="font-size: small;">Here</span></a> <span style="font-size: small;">is an important document prepared by G. Diane Shelton DVM, PhD, DACVIM to help veterinarians correctly distinguish and diagnose muscle disease in the vizsla.</span></span></span></div>
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<span style="color: #666666;"><span style="font-size: x-small;"><span style="font-size: small;">Below are links to some video clips that illustrate typical dysphagia. The food is not "vomited" Nor is it regurgitated from the oesophagus. Its problem is in leaving the mouth. It appears evident that the swallowing problem is at the level of the pharynx. We wonder too whether these vizslas' tongues are functioning properly. Sometimes normal lapping and licking seem not to be evident.</span></span></span></div>
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<span style="color: #666666;"><span style="font-size: x-small;"><span style="font-size: small;"><a href="http://www.youtube.com/watch?v=6golIXO9-_Q">View</a></span> <span style="font-size: small;">"Spice's" eating difficulties. Increasingly slimy food is returned to the bowl many times before successful swallowing can finally be achieved.</span></span></span></div>
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<span style="color: #666666;"><span style="font-size: x-small;"><span style="font-size: small;"><a href="http://www.youtube.com/watch?v=vaL0tLIVgUg">View</a></span> <span style="font-size: small;">"Spice's" drinking problems.Despite great effort the level of the water in the drinking bowl does not go down and eventually the bowl is full of slobber and food particles.</span></span></span></div>
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<span style="color: #666666;"><span style="font-size: x-small;"><span style="font-size: small;"><a href="http://www.youtube.com/watch?v=eidvPV__5oc">View</a></span> <span style="font-size: small;">how similar are "Amber's" efforts. This girl is luckier than many. She still has reasonably efficient tongue function and since immune suppressive treatment her</span> <span style="font-size: small;">swallowing too has improved. </span></span></span></div>
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<span style="color: #666666;"><span style="font-size: small;">In cases where the vizsla finds it difficult to eat from a bowl because of impaired tongue function then spoon-feeding can be helpful. <span style="font-size: small;"><a href="http://www.youtube.com/watch?v=nxeXqiHijt8">View</a></span> the technique.</span></span><br />
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<span style="color: #666666;"><span style="font-size: x-small;"> <span style="font-size: small;">We become increasingly interested in other immune mediated or "auto-immune " diseases in the vizsla. A new investigation is</span> <span style="color: #0c343d;"><span style="font-size: small;"><a href="http://www.vizslahealth.net/">here</a></span></span>. <span style="font-size: small;">Many
of our case study vizslas have had IBD (Inflammatory Bowel Disease) or
other GI (Gastro-Intestinal) problems. Skin problems and allergies too.
It becomes clear that many immune-mediated illnesses can be concommitant
(ie happening together) with polymyositis.</span></span></span><br />
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<span style="color: #666666;"><span style="font-size: small;">We would be very pleased indeed to hear from anybody who knows of a vizsla with the type of illnes</span>ses<span style="font-size: small;"> that we are describing. It is vital for the future wellbeing of this lovely breed that <i>everybody</i> with any information contacts us so that the widest possible picture can be discerned.</span></span></div>
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<span style="color: #666666;"><span style="font-size: x-small;"><br /></span><span style="font-size: small;">If you can help then please contact </span><span style="color: #073763;"><span style="font-size: small;">di.addico</span></span><span style="font-size: small;"><span style="color: #073763;">tt@gmail.com</span> </span><span style="font-size: small;">I am also </span><span style="font-size: x-small;"><span style="font-size: small;">delighted to speak on the telephone 01576 202258</span></span></span><br />
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<span style="color: #666666;"><span style="font-size: x-small;"><span style="font-size: small;">Please be assured that the sole purpose of the research is to determine the aetiology of this poorly defined illness and hopefully if possible to minimise its incidence. All information is treated with total confidence.</span></span></span><br />
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<span style="color: #666666;"><span style="font-size: x-small;"><span style="font-size: small;">We will be posting updates when we can. </span></span></span><br />
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Unknownnoreply@blogger.com